Neuroanesthesia & neurocritical care
Longitudinal trajectories of functional outcome following aneurysmal subarachnoid hemorrhage: a retrospective study
Authors' conclusion
Post-discharge recovery after aSAH is heterogeneous but often continues beyond three months. Pre-existing medical conditions seem to play an important role in outcome trajectories. Patients with moderate disability demonstrate the greatest potential for improvement
Study context
- Population
- Adults with imaging-confirmed aneurysmal SAH (aneurysmal subarachnoid hemorrhage (aSAH)) admitted to the neurocritical care unit of the University Hospital Zurich, January 2016–June 2024, who survived hospitalization and had follow-up at 3 and 12 monthsof 342 hospital survivors
- Participants
- 301 adults
- Outcome
- Functional improvement (increase in GOSE between 3 and 12 months)
- Follow-up
- 3 and 12 months
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Improvement on GOSE between 3 and 12 months · 3 to 12 months
Eligible survivors who improved on the Glasgow Outcome Scale-Extended (GOSE)
58.5%
Functional decline
≈ 6%
Observational data: associations, not effects.
Further findings
Improvement by GOSE at 3 months (excluding GOSE3 = 1 or 8)
- Improvement rates ranged from 38% to 71%, highest with moderate disability (GOSE at 3 months = 4)
Predictors of improvement: Charlson Comorbidity Index
- Higher Charlson Comorbidity Index (CCI) consistently associated with lower likelihood of improvement; not significant after multiplicity adjustment in primary multivariable logistic regression, nominally significant in ordinal shift sensitivity analysis
- Multiplicity-adjusted threshold not reached in primary model
Original publication
Longitudinal trajectories of functional outcome following aneurysmal subarachnoid hemorrhage: a retrospective study. Crit Care. Published 8 January 2026. doi:10.
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