Cardiac arrest & resuscitation
Lower versus higher oxygen targets after resuscitation from out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials
Pooled result · Short-term survival (in hospital or within 30 days)Result — go to the resultRR for short-term survival 0.98 95% CI 0.86–1.11Authors' conclusion
Current evidence suggests that targeting a lower or higher oxygen therapy in patients after resuscitation from OHCA results in similar short-term survival and other clinical outcomes.
Study context
- Population
- Adults resuscitated from out-of-hospital cardiac arrest (OHCA)
- Participants
- 1,454 adults · 7 randomized controlled trials (RCTs)
- Comparison
- Lower vs higher oxygen targets
- Outcome
- Short-term survival (in hospital or within 30 days)
Methodological detailssubgroup analyses by timing of study interventions, Quality of evidence ranged from moderate to very low
- Subgroup analyses by timing of study interventions
- Quality of evidence ranged from moderate to very low
Pooled result
As reported in the abstract
RR for short-term survival
0.98
95% CI 0.86–1.11
Lower oxygen targets vs Higher oxygen targets
RR for short-term survival 0.98 (95% CI 0.86–1.11)
Further pooled results
Survival at longest follow-up
- No significant difference between lower and higher oxygen targets
- 1.01 (RR, 1.01; 95% CI, 0.91 to 1.14)
Favorable neurological outcome
- No significant difference between lower and higher oxygen targets
- 1.00 (RR, 1.00; 95% CI, 0.91 to 1.11)
ICU LOS
- No significant difference between lower and higher oxygen targets
- −4.94 h (mean difference, −4.94 h; 95% CI, −14.83 to 4.96 h)
Re-arrest
- No significant difference between lower and higher oxygen targets
- 0.68 (RR, 0.68; 95% CI, 0.21 to 2.19)
Original publication
Lower versus higher oxygen targets after resuscitation from out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials. J Crit Care. Published 18 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →