Cardiac arrest & resuscitation
A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest
Authors' conclusion
Among comatose patients resuscitated from OHCA, targeting a higher MAP 180 min after ROSC did not significantly improve cerebral energy metabolism within 96 h of post-resuscitation care.
Study context
- Population
- Comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA)
- Participants
- 60 patients
- Comparison
- Low vs high MAP target
- Primary endpoint
- Time-averaged means of cerebral energy metabolites (jugular bulb microdialysis) during post-resuscitation care
Methodological detailsdouble-blinded, sub-study of the BOX trial
- Double-blinded
- Sub-study of the BOX trial
Primary result
As reported in the abstract
Cerebral LP ratio
Low MAP
19
range 16–31
High MAP
23
range 16–33
P = 0.64
Secondary outcomes
Median
| Outcome | Low MAP | High MAP | Difference (mmHg) | P value |
|---|---|---|---|---|
| Achieved MAP separation | 15 | P < 0.001 | ||
| rSO2 · first 48 h | 69.5% (IQR 62.0–75.0%) | 69.0% (IQR 61.3–75.5%) | P = 0.16 |
Cerebral metabolites (lactate > 2.5 mM, pyruvate > 110 µM, lactate-to-pyruvate (LP) ratio > 30, glycerol > 260 µM) predicting poor neurological outcome and death · first 24 h
- AUC
- 0.80
Original publication
A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest. Crit Care. Published 24 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →