Pediatric anesthesia & critical care
Lung-Protective Ventilation for Pediatric Acute Respiratory Distress Syndrome: A Nonrandomized Controlled Trial*
Authors' conclusion
Adherence to LPMV elements over the first week of PARDS was associated with reduced mortality.
Study context
- Population
- Invasively ventilated children with pediatric acute respiratory distress syndrome (PARDS) (PALICC 2015 definition), 21 PICUs
- Participants
- 693 participants · 21 PICUs
- Exposure
- Lung-protective mechanical ventilation (LPMV) protocol vs standard care
- LPMVn = 285
- non-LPMVn = 408reference
- Outcome
- 60-day mortality
- Follow-up
- 60 days
Methodological detailsmulticentre, prospective before-and-after comparison, pragmatic protocol
- Multicentre
- Prospective before-and-after comparison
- Pragmatic protocol
Main finding
As reported in the abstract
P = 0.104
Observational data: associations, not effects.
Further findings
60-day mortality by adherence to LPMV strategies (adjusted)
| aHR (95% CI) | P value | ||
|---|---|---|---|
| Adherence to LPMV strategiesLPMV protocol itself not associated · adjusted for confounders | 0.98 (0.97–0.99) | P = 0.004 | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | LPMV | non-LPMV | P value |
|---|---|---|---|
| Total adherence scoreImproved in LPMV | 57.1 (range 40.0–66.7) | 47.6 (range 31.0–58.3) | P < 0.001 |
60-day mortality by adherence to LPMV strategies (adjusted)
- Adherence to peak inspiratory pressure (PIP), delta/driving pressure (DP) and positive end-expiratory pressure (PEEP)/FiO2 combinations associated with reduced mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lung-Protective Ventilation for Pediatric Acute Respiratory Distress Syndrome: A Nonrandomized Controlled Trial*. Crit Care Med. Published 26 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →