Pediatric anesthesia & critical care
Lung Volume Change Under Apnoeic Oxygenation With Different Flow Rates in Children: A Single‐Centre Prospective Randomized Controlled Non‐Inferiority Trial
Authors' conclusion
Apnoeic oxygenation with low-flow is non-inferior to very high-flow regarding lung volume loss in children.
Study context
- Population
- Children (ASA 1 and 2, 10–20 kg) undergoing elective GA, apnoeic for 5 min after induction and NMB89 analysed
- Participants
- 108 children
- Comparison
- Low-flow, high-flow and early onset high-flow vs very high-flow apnoeic oxygenation
- Low-flown = 20
- High-flown = 24
- Very high-flown = 21reference
- Early onset high-flown = 24
- Primary endpoint
- Normalized reduction in lung volume in relation to body weight (mL kg-1) from start to end of apnoea, measured with electrical impedance tomography (EIT)
Methodological detailsnon-inferiority, single-centre, prospective
- Non-inferiority
- Single-centre
- Prospective
Primary result
As reported in the abstract
Reduction in lung volume
Low-flow
5.9
estimated mean · 95% CI 5.3–7.8 · mL kg-1
High-flow
6.5
estimated mean · 95% CI 5.3–7.8 · mL kg-1
Very high-flow
5.7
estimated mean · 95% CI 4.4–7.0 · mL kg-1
Early onset high-flow
6.7
estimated mean · 95% CI 5.5–7.9 · mL kg-1
Original publication
Lung Volume Change Under Apnoeic Oxygenation With Different Flow Rates in Children: A Single‐Centre Prospective Randomized Controlled Non‐Inferiority Trial. Paediatr Anaesth. Published 18 July 2025. doi:10.
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