Major adverse cardiovascular events are associated with necroptosis during severe COVID-19
Authors' conclusion
SARS-CoV-2 identification in the systemic circulation is associated with MACE and necroptosis activity.
Study context
- Population
- Patients with severe COVID-19; hamster infection models
- Participants
- 70 patients
- Exposure
- Patients with vs without major adverse cardiac events (MACE)
- MACEn = 18
- Outcome
- MACE and its association with necrotic cell death (necroptosis)
Methodological detailsanimal model (hamsters)
- Animal model (hamsters)
Main finding
As reported in the abstract
MACE incidence
MACE
26%
18
Observational data: associations, not effects.
Further findings
Serum antibody neutralisation of variant-of-concern spike pseudoviruses
- No differences
Hamster hearts: viral titres and cardiac transcriptome · 4 days post-infection
- Differential expression of total transcripts
- ≈9%
- Stark increase in cardiac viral titres
- Necroptosis (MLKL), but not pyroptosis (gasdermin D), elevated; pMLKL elevated in hamster hearts
Original publication
Major adverse cardiovascular events are associated with necroptosis during severe COVID-19. Crit Care. Published 20 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →