Anaesthetic drugs & techniques
Malignant hyperthermia in France: characteristics of 93 diagnosed patients in one French reference centre: A retrospective data analysis
Authors' conclusion
In this French cohort of 93 cases fully evaluated for MH susceptibility, the typical triad was present in 86% of MHS patients. Performance of Larach score as determined by this study was similar to its original description.
Study context
- Population
- Patients referred to a French malignant hyperthermia (MH) reference centre after a suspected MH crisis, 1968–2020fully investigated
- Participants
- 93 patients
- Exposure
- MH-susceptible vs MH-negative patients after suspected MH crisis
- MH-susceptible (MHS)n = 49
- MH-negative (MHN)n = 44reference
- Outcome
- Specific triad (hyperthermia, hypercapnia, muscle rigidity)
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
MHS
86%
Observational data: associations, not effects.
Further findings
Diagnostic performance of Larach score (threshold 45)
- Specificity
- 90% [87 to 93%]
- Sensitivity
- 59% [54 to 94%]
Adequate dantrolene treatment after 2000
- Cases given adequate dantrolene
- 64%
Original publication
Malignant hyperthermia in France: characteristics of 93 diagnosed patients in one French reference centre: A retrospective data analysis. Eur J Anaesthesiol. Published 29 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →