Maternal and neonatal outcomes in pregnant patients with Brugada Syndrome – a multicentre retrospective study (2014–2025)
Authors' conclusion
No episodes of arrhythmias were recorded in this cohort of pregnant patients with Brugada Syndrome who were exposed to neuraxial analgesia and anaesthesia.
Study context
- Population
- Pregnant patients with Brugada Syndrome, 12 maternity units in the UK and Ireland, 2014–2025
- Participants
- 57 patients · 64 pregnancies
- Outcome
- Arrhythmia during labour and delivery
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- No arrhythmia events recorded during labour and delivery
Observational data: associations, not effects.
Further findings
Pregnancy outcome
- Live births
- 62 (96.9%)
- Terminations
- two (3.1%)
Pre-pregnancy counselling documented (diagnosed pre-pregnancy, n=53)
- Counselling documented
- 37.7% (20/53)
Mode of delivery
- Caesarean delivery
- 42.2%
- Vaginal deliveries
- 37.5%
- Instrumental deliveries
- 17.2%
Labour analgesia (48 labouring patients)
- Neuraxial labour analgesia
- 35.5%
- Systemic opioids
- 25%
- 50:50 oxygen: nitrous oxide as sole analgesic
- 18.8%
Anaesthesia for caesarean delivery
- Neuraxial anaesthesia in caesarean deliveries
- 96.3%
- GA using propofol: one caesarean and both surgical terminations
PPH rate
- PPH rate
- 38.7%
- As printed: "38.7% uterotonics"
Implantable cardioverter-defibrillator management
- Deactivated during interventions in theatre
- four
Neonatal outcomes
- Preterm birth
- 6.5%
- Neonatal ICU admission
- 1.6%
Original publication
Maternal and neonatal outcomes in pregnant patients with Brugada Syndrome – a multicentre retrospective study (2014–2025). Int J Obstet Anesth. Published 8 May 2026. doi:10.
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