Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study
Authors' conclusion
Patients with both preeclampsia and preeclampsia with severe features have higher rates of maternal cardiovascular morbidity events than those without preeclampsia.
Study context
- Population
- Obstetric patients older than 18 years who delivered from January 1, 2016, to September 30, 2020
- Participants
- 4,488,759 participants
- Exposure
- Preeclampsia without severe features and preeclampsia with severe features vs no preeclampsia
- Preeclampsia without severe featuresn = 158,114
- Preeclampsia with severe featuresn = 117,940
- Outcome
- Composite of maternal cardiovascular morbidity events
- Follow-up
- During delivery hospital admission
Methodological detailsPremier inpatient database
- Premier inpatient database
Main finding
As reported in the abstract
delivery hospitalization
Each group vs without preeclampsiaAdjusted odds ratio (95% CI)
Preeclampsia without severe features
1.87(1.78–1.97)
Preeclampsia with severe features
4.74(4.44–5.05)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| Maternal cardiovascular morbidity events during readmission · within 90 days of delivery hospitalizationPreeclampsia without severe features vs Without preeclampsia | 2.01 (1.83–2.21) | |
| Maternal cardiovascular morbidity events during readmission · within 90 days of delivery hospitalizationPreeclampsia with severe features vs Without preeclampsia | 2.32 (2.10–2.57) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study. Anesth Analg. Published 13 December 2022. doi:10. 1213/ ane. 0000000000006310
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