Obstetric anesthesia

Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study

Anesth AnalgPublished Retrospective cohort study

Authors' conclusion

Patients with both preeclampsia and preeclampsia with severe features have higher rates of maternal cardiovascular morbidity events than those without preeclampsia.

Study context

Population
Obstetric patients older than 18 years who delivered from January 1, 2016, to September 30, 2020
Participants
4,488,759 participants
Exposure
Preeclampsia without severe features and preeclampsia with severe features vs no preeclampsia
  • Preeclampsia without severe featuresn = 158,114
  • Preeclampsia with severe featuresn = 117,940
Outcome
Composite of maternal cardiovascular morbidity events
Follow-up
During delivery hospital admission
Methodological detailsPremier inpatient database
  • Premier inpatient database

Main finding

As reported in the abstract

delivery hospitalization
Each group vs without preeclampsiaAdjusted odds ratio (95% CI)
Preeclampsia without severe features
1.87(1.78–1.97)
Preeclampsia with severe features
4.74(4.44–5.05)

Observational data: associations, not effects.

Secondary outcomes

OutcomeaOR (95% CI)
Maternal cardiovascular morbidity events during readmission · within 90 days of delivery hospitalizationPreeclampsia without severe features vs Without preeclampsia2.01 (1.83–2.21)
Maternal cardiovascular morbidity events during readmission · within 90 days of delivery hospitalizationPreeclampsia with severe features vs Without preeclampsia2.32 (2.10–2.57)

Original publication

Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study. Anesth Analg. Published 13 December 2022. doi:10.1213/ane.0000000000006310

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