Perioperative medicine & outcomes
MCT1 transporter polymorphism and postoperative hyperlactataemia after major abdominal surgery
Authors' conclusion
The MCT1 rs1049434 polymorphism was not associated with differential lactate trajectories over time but was associated with a shift in postoperative lactate levels. These findings suggest that genetic variability in lactate transport may influence the interpretation of perioperative lactate values. The observed association with postoperative complications should be considered exploratory and requires confirmation in larger studies.
Study context
- Population
- Patients undergoing major abdominal surgerypatients analysed
- Participants
- 109 patients
- Exposure
- Association between the MCT1 rs1049434 polymorphism (number of T alleles, additive model) and postoperative lactate levels and outcomes
- Outcome
- Postoperative lactate levels over time
Main finding
As reported in the abstract
- Lactate levels increased over time in all patients, peaking 3 hours after surgery
Observational data: associations, not effects.
Further findings
| Outcome | OR (per T allele) (95% CI) | P value | |
|---|---|---|---|
| Postoperative complicationsMultivariable analysis | 2.23 (1.22–4.10) | P = 0.009 | |
| 0.20.5125Odds ratio (log scale) |
- Postoperative complications: Firth penalised logistic regression (additive model), adjusted for body mass index, mean arterial pressure, and surgery duration
- Postoperative complications: should be interpreted with caution given the limited sample size
Postoperative lactate trajectories (genotype-by-time interaction)
- No significant genotype-by-time interaction was observed
- Adjusted estimates suggested a consistent upward shift in lactate levels among T-allele carriers
- Linear mixed-effects models
Original publication
MCT1 transporter polymorphism and postoperative hyperlactataemia after major abdominal surgery. Anaesth Crit Care Pain Med. Published 7 October 2026. doi:10.
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