Measurements of pupillary unrest using infrared pupillometry fail to detect changes in pain intensity in patients after surgery: a prospective observational study
Main finding · PUALResult — go to the resultDifference in means −0.001 95% CI −0.018 to 0.015Authors' conclusion
In this prospective observational study, pupillometric measurements of pupillary unrest did not identify changes in pain intensity in a postoperative, predominantly opioid-exposed patient population.
Study context
- Population
- Patients with unsatisfactory pain control after surgery undergoing RA procedures, academic surgery centre
- Participants
- 18 patients
- Exposure
- Pupillary unrest in ambient light (PUAL) and NRS pain scores before vs after regional anaesthesia block
- Before analgesian = 18reference
- After analgesian = 18
- Outcome
- Change in pupillary unrest in ambient light (PUAL, infrared pupillometry) vs change in NRS pain scores (0-10)
Methodological detailssingle-centre, before-after
- Single-centre
- Before-after
Main finding
PUAL
Difference in means
−0.001
95% CI −0.018 to 0.015
P = 0.88
By group
Before analgesia
0.113
mean · SD 0.062
After analgesia
0.112
mean · SD 0.068
After analgesia vs Before analgesia
difference in means −0.001 (95% CI −0.018 to 0.015); P = 0.88
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean
| Outcome | Before analgesia | After analgesia | Difference in means (95% CI) | P value |
|---|---|---|---|---|
| NRS pain score | 7.2 (SD 1.7) | 1.9 (SD 1.8) | −2.2 (−6.3 to −4.1) | P < 0.001 |
Original publication
Measurements of pupillary unrest using infrared pupillometry fail to detect changes in pain intensity in patients after surgery: a prospective observational study. Can J Anaesth. Published 19 March 2024. doi:10.
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