Median effective dose (ED50) of intrathecal ropivacaine for labor analgesia initiation in nulliparous vs. multiparous women: an up-down sequential allocation study
Authors' conclusion
The median effective dose of intrathecal ropivacaine for labour analgesia is greater in multiparous than in nulliparous women during spontaneous latent phase labor.
Study context
- Population
- Nulliparous and multiparous women receiving CSE for labor analgesia
- Participants
- 30 vs 30
- Comparison
- Nulliparous vs Multiparous
- Nulliparousn = 30reference
- Multiparousn = 30
- Outcome
- Median effective dose (ED50) of intrathecal ropivacaine; effective analgesia = NRS ≤3 within 10 min after intrathecal administration
Methodological detailsDixon and Massey sequential method, Probit regression, First dose 3.0 mg intrathecal ropivacaine; subsequent doses adjusted in 0.3 mg steps
- Dixon and Massey sequential method
- Probit regression
- First dose 3.0 mg intrathecal ropivacaine; subsequent doses adjusted in 0.3 mg steps
Main finding
As reported in the abstract
ED50 of intrathecal ropivacaine
Original publication
Median effective dose (ED50) of intrathecal ropivacaine for labor analgesia initiation in nulliparous vs. multiparous women: an up-down sequential allocation study. Int J Obstet Anesth. Published 1 March 2026. doi:10.
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