Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial
Primary resultResult — go to the resultRelative risk 0.96 95% CI 0.81–1.13Authors' conclusion
In critically ill patients with sepsis, compared with intermittent administration, the continuous administration of meropenem did not improve the composite outcome of mortality and emergence of pandrug-resistant or extensively drug-resistant bacteria at day 28.
Study context
- Population
- Critically ill patients with sepsis or septic shock prescribed meropenem, 31 ICUs of 26 hospitals in 4 countries (Croatia, Italy, Kazakhstan, Russia)all included in primary analysis
- Participants
- 607 patients
- Comparison
- Continuous vs intermittent meropenem administration
- Continuous administrationn = 303
- Intermittent administrationn = 304reference
- Primary endpoint
- Composite of all-cause mortality and emergence of pandrug-resistant or extensively drug-resistant bacteria
- Follow-up
- Day 28
Methodological detailsdouble-blind, multicentre, Only 1 crossover event recorded, Enrolled June 5, 2018–August 9, 2022; 90-day follow-up completed November 2022
- Double-blind
- Multicentre
- Only 1 crossover event recorded
- Enrolled June 5, 2018–August 9, 2022; 90-day follow-up completed November 2022
Primary result
As reported in the abstract
Relative risk
0.96
95% CI 0.81–1.13
P = 0.60
Events by treatment group
Continuous administration vs Intermittent administration
RR 0.96 (95% CI 0.81–1.13); P = 0.60
Secondary outcomes
All-cause mortality · 90 days
4 secondary outcomes (days alive and free from antibiotics and from ICU at day 28, all-cause mortality at day 90)
- None statistically significant
Safety
- No adverse events of seizures or allergic reactions related to the study drug reported
Original publication
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial. JAMA. Published 11 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →