Cardiac arrest & resuscitation
Metabolic profiles associate with mortality and neurological outcomes in out-of-hospital cardiac arrest patients
Authors' conclusion
This study identifies distinct metabolic profiles associated with neurological recovery after cardiac arrest, suggesting a potential link between metabolic states and outcomes that may reflect adaptive brain resilience.
Study context
- Population
- Consecutive unconscious out-of-hospital cardiac arrest (OHCA) patients in the Targeted Temperature Management trial, blood sampled at hospital admission
- Participants
- 156 patients
- Comparison
- Metabolic profile clusters A vs B vs C
- Primary endpoint
- Mortality and neurological outcomes across metabolic clusters
- Follow-up
- 30 days
Methodological detailshierarchical clustering, consecutive patients
- Hierarchical clustering
- Consecutive patients
Primary result
As reported in the abstract
30-day mortality
P < 0.001
Further findings
Neurological deaths
- Lowest in Cluster C
Baseline FFA levels and neurological death
- Baseline FFA levels independently associated with neurological death
Cardiac arrest severity
- Cluster A linked to greater severity: longer time to return of spontaneous circulation (ROSC), more defibrillations, higher adrenaline use
Original publication
Metabolic profiles associate with mortality and neurological outcomes in out-of-hospital cardiac arrest patients. Resuscitation. Published 14 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →