Cardiac arrest & resuscitation
Combined short- and mid-latency SSEP amplitudes for early prediction of favorable neurological recovery after cardiac arrest
Authors' conclusion
Quantitative assessment of the P25-N30 amplitude within 24 h after cardiac arrest was associated with favorable neurological outcome
Study context
- Population
- Comatose adult cardiac arrest patients treated with targeted temperature management, 2009–2023, with SSEP recording within 24 h after return of spontaneous circulation (ROSC)29 (40%) favorable outcome
- Participants
- 73 patients
- Exposure
- P25-N30 amplitude vs N20-P25 amplitude
- Outcome
- Favorable neurological outcome (Cerebral Performance Category (CPC) 1-2)
- Follow-up
- 6 months
Main finding
As reported in the abstract
Discrimination of favorable neurological outcome
| Group | AUC | Sensitivity | Specificity |
|---|---|---|---|
| P25-N30 amplitude | 0.943 (95% CI 0.862-0.984) | 100% (95% CI 88.1-100%) | 84.1% (95% CI 69.9-93.4%) |
| N20-P25 amplitude | 0.922 (95% CI 0.836-0.972) | — not stated in the abstract | — not stated in the abstract |
AUC
P25-N30 amplitude0.943 (95% CI 0.862-0.984)
N20-P25 amplitude0.922 (95% CI 0.836-0.972)
Sensitivity
P25-N30 amplitude100% (95% CI 88.1-100%)
N20-P25 amplitude— not stated in the abstract
Specificity
P25-N30 amplitude84.1% (95% CI 69.9-93.4%)
N20-P25 amplitude— not stated in the abstract
— not stated in the abstract
- P25-N30 amplitude vs N20-P25 amplitude: P = 0.417 — comparable
Observational data: associations, not effects.
Further findings
Cortical SSEP amplitudes
- Consistently higher in patients with favorable outcomes
Addition of non-SSEP predictors
- Did not significantly improve overall discrimination
Original publication
Combined short- and mid-latency SSEP amplitudes for early prediction of favorable neurological recovery after cardiac arrest. Resuscitation. Published 30 April 2026. doi:10.
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