Cardiac arrest & resuscitation
Optimal mean arterial pressure for favorable neurological outcomes in patients after cardiac arrest
Authors' conclusion
Machine learning analysis identified MAP as a major predictor of favorable neurological outcomes, with higher variable importance during the first 6 h after ROSC. MAP showed an inverted U-shaped relationship with favorable neurological outcomes, with an optimal threshold of approximately 80 mmHg.
Study context
- Population
- Post-cardiac arrest patients, first 24 h after return of spontaneous circulation (ROSC), tertiary care center
- Participants
- 291 patients
- Outcome
- Favorable neurological outcomes:
- Association with hourly MAP
- Optimal MAP range
Methodological detailssingle-centre (tertiary care center), machine learning (Random Forest), SHAP and LIME interpretation
- Single-centre (tertiary care center)
- Machine learning (Random Forest)
- SHAP and LIME interpretation
Main finding
As reported in the abstract
Optimal MAP threshold for favorable neurological outcomes (SHAP) · first 24 h after ROSC
Inverted U-shaped relationship between mean arterial pressure (MAP) and favorable neurological outcomes; optimal threshold (IQR: 73.70-82.54)
79.56 mmHg
Observational data: associations, not effects.
Further findings
Optimal MAP threshold by time window
mmHg
- Early (1-6 h)
- 79.26
- Later (7-24 h)
- 80.09
- Threshold consistent across early and later hours
Individual-level explanations (SHAP and LIME)
- Maintaining higher MAP during early post-resuscitation period contributed positively to outcome predictions
Original publication
Optimal mean arterial pressure for favorable neurological outcomes in patients after cardiac arrest. J Intensive Care. Published 31 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →