Pediatric anesthesia & critical care
Metabolomic profiling of pediatric post‐tonsillectomy pain: A proof‐of‐concept study
Authors' conclusion
This study identified novel candidate biomarker panels that effectively differentiated varying severity of post-tonsillectomy pain.
Study context
- Population
- Children undergoing tonsillectomy ± adenoidectomy
- Participants
- 34 children
- Comparison
- Mild vs Moderate vs Severe
- Mildn = 6reference
- Moderaten = 14
- Severen = 14
- Outcome
- Candidate serum metabolites associated with varying severity of post-tonsillectomy pain
Main finding
As reported in the abstract
Candidate biomarker panels discriminating pain severity
Severe vs mild: 4 metabolites (fatty acid 18:0(OH), thyroxine, phosphatidylcholine 38:5, branched fatty acids C27H54O3), combined AUC
0.91
Moderate vs mild: 4 metabolites (sebacic acid, dicarboxylic acids C18H34O4, hydroxy fatty acids C18H34O3, myristoleic acid), AUC range
0.85 to 0.95
Original publication
Metabolomic profiling of pediatric post‐tonsillectomy pain: A proof‐of‐concept study. Paediatr Anaesth. Published 11 March 2024. doi:10.
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