Minimum effective volume 90% for ultrasound-guided selective trunk block: A quantal bioassay
Authors' conclusion
The MEV90 of a 1 : 1 LA mixture for USG SeTB to produce surgical anaesthesia of the entire upper extremity (except for the T2 dermatome), using readiness for surgery as the success criterion, is 24.7 ml (95% CI, 23.8 to 28.9) ml.
Study context
- Population
- ASA I to III patients aged 18 to 75 years undergoing upper extremity surgery under ultrasound-guided (USG) selective trunk block (SeTB), University hospital in Hong Kong S.A.R, China
- Participants
- 25 participants
- Outcome
- Readiness for surgery (sensory score ≤30 and motor score ≤1); MEV90 of local anaesthetic (LA) (1 : 1 mixture of 2% lidocaine with 5 μg ml −1 epinephrine and 0.5% levobupivacaine) for SeTB
- Follow-up
- At or within 30 min after the injection
Methodological detailssingle-centre, modified Narayana sequential design, centred isotonic regression
- Single-centre
- Modified Narayana sequential design
- Centred isotonic regression
Main finding
As reported in the abstract
MEV90 of the LA mixture for USG SeTB
MEV90 (95% CI 23.8 to 28.9) ml
24.7
Further findings
Time to readiness for surgery
- Median [IQR 5 to 12.3] minutes
- 6.6
Time to complete anaesthesia
- Median [IQR 7.3 to 18] minutes
- 15
Original publication
Minimum effective volume 90% for ultrasound-guided selective trunk block: A quantal bioassay. Eur J Anaesthesiol. Published 11 March 2025. doi:10.
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