Perioperative medicine & outcomes
Mismatch of populations between randomised controlled trials of perioperative interventions in major abdominal surgery and current clinical practice
Authors' conclusion
Patients encountered in our current local clinical practice are significantly different from those in our defined set of perioperative RCTs.
Study context
- Population
- Adults undergoing major abdominal surgery: participants in perioperative multicentre RCTs vs local clinical practice patients106 trials
- Comparison
- RCT participants vs real-world clinical practice patients
- Outcome
- Mismatch in age, weight, BMI and ASA grade between trial participants and clinical practice patients
Methodological detailsmulticentre RCTs, single-institution reference sample
- Multicentre RCTs
- Single-institution reference sample
Pooled result
As reported in the abstract
Trials mismatched on at least one characteristic (age, weight, BMI, ASA)
Trials mismatched on ≥1 characteristic
94.3%
Further pooled results
| Outcome | Values |
|---|---|
| Time since trial publication | Trials median 13.4 (IQR [range] 5-20 [0-35]) years |
Change in recruitment by ASA grade over time since publication
- ASA 3+ recruitment increased over time (Spearman's Rho)
- 0.58
- ASA 1 recruitment decreased over time (Spearman's Rho)
- - 0.44
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mismatch of populations between randomised controlled trials of perioperative interventions in major abdominal surgery and current clinical practice. Perioper Med (Lond). Published 16 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →