Moderate IV Fluid Resuscitation Is Associated With Decreased Sepsis Mortality
Main finding · Risk-adjusted mortalityResult — go to the resultReduction in risk-adjusted mortality 2.5%Authors' conclusion
Individual physician practice drives excess variation in the amount of IV fluid given to patients with sepsis. A moderate approach to IV fluid resuscitation is associated with decreased sepsis mortality
Study context
- Population
- Patients with sepsis and septic shock admitted from the ED to the ICU, 612 US hospitals, 2016–2019
- Participants
- 190,682 patients · 612 US hospitals
- Exposure
- Moderate vs very low or very high IV fluid resuscitation
- Outcome
- Sepsis mortality
Methodological detailsadministrative database (Premier Healthcare Database), multicentre
- Administrative database (Premier Healthcare Database)
- Multicentre
Main finding
Risk-adjusted mortality
Reduction in risk-adjusted mortality
2.5%
P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
Variation in mean IV fluid administered
- Predicted mean range (95% range)
- 3.6-4.5 L
- Observed mean range (95% range)
- 1.7-7.4 L
Source of practice variation
- Physician variation within hospitals, not differences between hospitals, accounts for the observed variation
Original publication
Moderate IV Fluid Resuscitation Is Associated With Decreased Sepsis Mortality. Crit Care Med. Published 23 August 2024. doi:10.
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