Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing
Pooled result · Sepsis endotypes (unsupervised clustering) and mortalityResult — go to the resultOdds ratio 2.19 95% CI 1.04–4.78Authors' conclusion
This multicohort RNA-seq meta-analysis identified three biologically and clinically distinct sepsis endotypes characterized by coagulopathic, adaptive, and inflammatory responses.
Study context
- Population
- Adults with sepsis in publicly available RNA-seq datasets4 datasets
- Participants
- 280 adults
- Comparison
- Coagulopathic vs inflammatory vs adaptive endotype
- Coagulopathicn = 83
- Inflammatoryn = 118
- Adaptiven = 79reference
- Outcome
- Sepsis endotypes (unsupervised clustering) and mortality
Methodological detailsmulticohort transcriptomic study, unsupervised consensus clustering, external validation cohort
- Multicohort transcriptomic study
- Unsupervised consensus clustering
- External validation cohort
Pooled result
As reported in the abstract
Odds ratio
2.19
95% CI 1.04–4.78
P = 0.04
By group
Coagulopathic vs Adaptive
OR 2.19 (95% CI 1.04–4.78); P = 0.04
Further pooled results
| Outcome | Coagulopathic | Adaptive | P value |
|---|---|---|---|
| External validation cohort: mortality, coagulopathic vs adaptive | 34% | 18% | P = 0.10 |
External validation cohort: mortality, coagulopathic vs adaptive
- Three endotypes consistently identified in validation cohort of 123 patients using 14 gene classifiers
Original publication
Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing. J Intensive Care. Published 30 May 2025. doi:10.
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