Morphine and hydromorphone pharmacokinetics in human volunteers: population-based modelling of interindividual and opioid-related variability
Authors' conclusion
Morphine and hydromorphone did not differ in a statistically significant or clinically meaningful manner in their interindividual pharmacokinetic variability.
Study context
- Population
- Healthy volunteerscrossover
- Participants
- 51 volunteers
- Comparison
- i.v. hydromorphone vs i.v. morphine, 2-h infusion, 1-2 weeks apart
- Primary endpoint
- Interindividual variability in pharmacokinetics (%CV of individual model parameters)
Methodological detailspopulation pharmacokinetic modelling, population modelling (NONMEM)
- Population pharmacokinetic modelling
- Population modelling (NONMEM)
Primary result
As reported in the abstract
Interindividual PK variability, structural model parameters (combined analysis)
Interindividual variabilities comparable for hydromorphone and morphine; %CV range for structural model parameters
9% to 31%
Further findings
Residual error variability (combined analysis)
- Additive residual error, comparable for morphine and hydromorphone
- 20-40%
- Relative residual error, comparable for morphine and hydromorphone
- 72-87%
Original publication
Morphine and hydromorphone pharmacokinetics in human volunteers: population-based modelling of interindividual and opioid-related variability. Br J Anaesth. Published 26 November 2024. doi:10.
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