Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers
Authors' conclusion
For morphine compared to hydromorphone, analgesia and analgesia relative to respiratory depression were less, onset of miosis and respiratory depression was later, and duration of respiratory depression was longer.
Study context
- Population
- Healthy volunteerscrossover
- Participants
- 42 volunteers
- Comparison
- IV morphine vs hydromorphone, 2-h infusion
- Primary endpoint
- Onset, magnitude, duration and variability of analgesic and ventilatory effects
- Follow-up
- 12 h after dosing
Methodological detailshealthy volunteers
- Healthy volunteers
Primary result
As reported in the abstract
- Less analgesia and less analgesia relative to respiratory depression with morphine vs hydromorphone
Further findings
Maximum miosis
P < 0.001
Time to maximum miosis
P < 0.001
Maximum tolerated temperature
P < 0.001
Area under temperature tolerance-time curve
P < 0.001
Mean
| Outcome | Morphine | Hydromorphone | P value |
|---|---|---|---|
| Verbal pain score at 48.2°C stimulus · end-infusion | 82 (SD 4) | 59 (SD 3) | P < 0.001 |
Interindividual variability in clinical effects
- Did not differ between opioids
Safety
Maximum end-expired CO2
P = 0.007
Time to maximum end-expired CO2
P < 0.001
Respiratory rate nadir
P < 0.001
Respiratory rate nadir
- Nadir occurred at similar times
Original publication
Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers. Anesthesiology. Published 4 April 2023. doi:10.
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