Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group
Main finding · In-hospital mortality (propensity score matched)Result — go to the resultDifference [Formula: see text] 3.4% 95% CI [Formula: see text] 3.7 to [Formula: see text] 3.1Authors' conclusion
Herein, using the nationwide medical claims database, we demonstrated that ICU admission was potentially associated with decreasing in-hospital mortality among sepsis patients.
Study context
- Population
- Adults aged over 20 years with presumed serious infection and organ failure (sepsis), Japan nationwide medical claims database, 2010 to 2017
- Participants
- 1,167,901 adults
- Exposure
- Intensive care unit (ICU) vs non-ICU management
- ICUn = 193,612
- Non-ICUn = 974,289reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide medical claims database, propensity score matching, multivariable logistic regression
- Nationwide medical claims database
- Propensity score matching
- Multivariable logistic regression
Main finding
In-hospital mortality (propensity score matched)
Difference
[Formula: see text] 3.4%
95% CI [Formula: see text] 3.7 to [Formula: see text] 3.1
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | ICU | Non-ICU | Difference (95% CI) | |
|---|---|---|---|---|
| In-hospital mortality, unadjustedUnadjusted | 26.2% | 22.5% | 3.7% (3.5–3.9) | |
| −2024Difference (linear scale) |
| Outcome | Mortality difference (95% CI) |
|---|---|
| In-hospital mortality, adults 20 ≤ age ≤ 64 (sensitivity analysis)Sign printed as formula · sensitivity analysis | 2.7% ([Formula: see text] 3.3 to [Formula: see text] 2.2) |
| In-hospital mortality, independent patients (sensitivity analysis)Sign printed as formula · sensitivity analysis | 5.8% ([Formula: see text] 6.4 to [Formula: see text] 5.2) |
| In-hospital mortality, patients without malignant tumors (sensitivity analysis)Sign printed as formula · sensitivity analysis | 1.3% ([Formula: see text] 1.7 to [Formula: see text] 1.0) |
In-hospital mortality, multivariable logistic regression analysis
- In-hospital mortality difference with multivariable regression, comparable with propensity score matching results (sign printed as formula)
- 5.0% [95% CI [Formula: see text] 5.2 to [Formula: see text] 4.8]
Original publication
Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group. J Intensive Care. Published 7 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →