Pediatric anesthesia & critical care
Mortality in children with fulminant myocarditis: a six-year multicenter retrospective study
Authors' conclusion
Peak lactate, CK-MB, and ventricular tachycardia are early independent predictors of in-hospital mortality in pediatric FM.
Study context
- Population
- Children <18 years with fulminant myocarditis admitted to eight ECMO-capable PICUs, January 2018–August 2023157 (84.0%) required ECMO
- Participants
- 187 children
- Outcome
- In-hospital mortality (predictors)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
In-hospital mortality and its predictors
- In-hospital mortality
- 16.6% (31/187)
- Peak lactate, independent predictor (AUC)
- 0.791
- CK-MB, independent predictor (AUC)
- 0.774
- Peak lactate + ventricular tachycardia model (AUC)
- 0.772
- CK-MB + peak lactate + ventricular tachycardia model, best performance (AUC)
- 0.815
Observational data: associations, not effects.
Further findings
Lactate 12 h after initiation of ECMO or intensive conventional therapy and mortality
| OR (95% CI) | ||
|---|---|---|
| Elevated lactate at 12 h | 1.219 (1.004–1.481) | |
| 0.512Odds ratio (log scale) |
Univariate predictors of mortality
- Elevated CK-MB, higher peak lactate and ventricular tachycardia associated with mortality
- Univariate analysis
Original publication
Mortality in children with fulminant myocarditis: a six-year multicenter retrospective study. Ann Intensive Care. Published 23 January 2026. doi:10.
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