ICU sedation, delirium & recovery
Multicentre implementation of a quality improvement initiative to reduce delirium in adult intensive care units: An interrupted time series analysis
Authors' conclusion
An ABCDEF delirium initiative was implemented on a population-basis within adult ICUs and was successful at reducing the prevalence of delirium.
Study context
- Population
- Adult admissions to 15 general medical/surgical and/or neurologic intensive care unit (ICUs) in Alberta, Canada, 2014–201938,400 unique patients
- Participants
- 44,405 admissions
- Exposure
- Pre-intervention vs Post-intervention
- Outcome
- Proportion of delirium days per ICU
Methodological detailssegmented linear regression with mixed effects models, multicentre, population-based
- Segmented linear regression with mixed effects models
- Multicentre
- Population-based
Main finding
As reported in the abstract
After implementation, 2017
33.48%
95%CI 29.64–37.31%
After implementation, 2019
28.74%
95%CI 25.22–32.26%
Observational data: associations, not effects.
Further findings
Proportion of sedation days using midazolam
- Immediate decrease after implementation
- 7.58% (95%CI 4.00-11.16%)
Duration of invasive ventilation, partial coma days, ICU mortality
- No significant changes
Safety
Potential adverse events
- No significant changes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Multicentre implementation of a quality improvement initiative to reduce delirium in adult intensive care units: An interrupted time series analysis. J Crit Care. Published 10 January 2024. doi:10.
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