Multimodal analgesia with continuous nerve blocks versus intravenous patient-controlled analgesia for pancreatectomy: a retrospective cohort study
Authors' conclusion
MMA with continuous peripheral nerve blocks provides effective analgesia, reduces opioid consumption, and facilitates early mobilization compared to IV PCA in pancreatectomy patients.
Study context
- Population
- Patients undergoing open pancreatectomy (pancreaticoduodenectomy or distal pancreatectomy), March 2021–April 2024
- Participants
- 104 patients
- Exposure
- MMA with continuous peripheral nerve blocks vs IV PCA
- MMAn = 42
- PCAn = 62reference
- Outcome
- Pain scores
- Follow-up
- Through POD 3
Methodological detailssingle-centre, multivariable regression, generalized estimating equations
- Single-centre
- Multivariable regression
- Generalized estimating equations
Main finding
As reported in the abstract
POD 1
- MMA vs PCA: P = 0.002
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Morphine consumption · 72 hoursLower in MMA | P < 0.001 |
Mobilization and 14-day readmissions
- Earlier mobilization and fewer 14-day readmissions in MMA vs PCA
Morbidity, mortality, unexpected ICU admission, hospital LOS
- No significant differences between groups
Safety
- Less nausea and vomiting with MMA than PCA
- No serious adverse events in either group
Original publication
Multimodal analgesia with continuous nerve blocks versus intravenous patient-controlled analgesia for pancreatectomy: a retrospective cohort study. Perioper Med (Lond). Published 14 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →