Perioperative medicine & outcomes
Multimodal prehabilitation and perioperative immune function in patients undergoing abdominal cancer surgery
Authors' conclusion
This study suggests that multimodal prehabilitation influences basal immune function, leading to a less inflammatory state. However, as no significant differences in immune function were observed between the prehabilitation and control groups on POD1, the impact of prehabilitation on postoperative immune function may be limited.
Study context
- Population
- Patients undergoing elective bladder, oesophageal or rectal cancer surgery, June 2022–November 2023
- Participants
- 130 patients
- Comparison
- Multimodal prehabilitation vs usual care
- Prehabilitationn = 102
- Controln = 28reference
- Primary endpoint
- Immune function (ex vivo cytokine production capacity, plasma cytokine concentrations, monocytic human leucocyte antigen DR (mHLA-DR) expression)
- Follow-up
- Baseline, after prehabilitation or usual care interval, and POD1
Methodological detailsexploratory
- Exploratory
Primary result
As reported in the abstract
Preoperative immune function after prehabilitation · after the prehabilitation interval
- Ex vivo production of pro-inflammatory cytokines reduced after prehabilitation
- Ex vivo production of anti-inflammatory IL-10 increased after prehabilitation
- Plasma IL-6 and IL-10 lower after prehabilitation
- Exploratory
Further findings
Postoperative immune function · POD1
- No significant differences between prehabilitation and control groups
Original publication
Multimodal prehabilitation and perioperative immune function in patients undergoing abdominal cancer surgery. Br J Surg. Published 6 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →