Multiple-site decontamination to prevent acquired infection in patients with veno-venous extra corporeal membrane oxygenation (ECMO) support
Main finding · ECMO-AIResult — go to the resultIncidence rate ratio 0.42 95% CI 0.23–0.60Authors' conclusion
In this cohort of patients from different hospitals, MSD appeared to be safe in ECMO patients and may be associated with improved outcomes including lower ECMO-AI and MDRO acquisition incidences.
Study context
- Population
- Adults (> 18 years old) receiving VV-ECMO for ARDS in three French ECMO referral centers, January 2010 to December 2021
- Participants
- 241 adults · 3 centres
- Exposure
- Multiple-site decontamination plus standard care vs standard care
- Multiple-site decontamination (MSD)n = 69
- Standard care (SC)n = 172reference
- Outcome
- ECMO-associated acquired infection (ECMO-associated infection (ECMO-AI)), including ventilator-associated pneumonia (VAP) and bloodstream infection
Methodological detailsmulticentre, propensity-score matching (sensitivity)
- Multicentre
- Propensity-score matching (sensitivity)
Main finding
ECMO-AI
Incidence rate ratio
0.42
95% CI 0.23–0.60
P < 0.001
Events by group
MSD
19
events
SC
143
events
MSD vs SC
IRR 0.42 (95% CI 0.23–0.60); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | MSD | SC | IRR (95% CI) | P value | |
|---|---|---|---|---|---|
| MDRO acquisition | two events | 30 events | 0.13 (0.03–0.56) | P = 0.001 | |
| 0.050.21520Incidence rate ratio (log scale) |
ICU mortality · similar in both groups
P = 0.90
Original publication
Multiple-site decontamination to prevent acquired infection in patients with veno-venous ECMO support. Ann Intensive Care. Published 7 April 2023. doi:10.
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