Perioperative medicine & outcomes
Myocardial Injury After Noncardiac Surgery in Major General Surgical Patients a Prospective Observational Cohort Study
Main finding · 30-day all-cause mortalityResult — go to the resultAdjusted odds ratio 4.7 95% CI 3.0–7.4Authors' conclusion
Approximately 1 in 6 patients experienced MINS after major general surgery. MINS was independently associated with a nearly 5-fold increase in 30-day mortality. The vast majority of patients with MINS were asymptomatic and would have gone undetected without routine postoperative troponin measurement.
Study context
- Population
- Major general surgery patients aged 45 years or older, 24 centres in 13 countriesof 22,552 noncardiac surgery patients
- Participants
- 4,490 patients
- Exposure
- MINS vs no MINS
- Outcome
- 30-day all-cause mortality associated with MINS
- Follow-up
- 30 days
Methodological detailsinternational, multicentre, high-sensitivity troponin T (hsTnT) measured during the first 3 postoperative days in all patients
- International
- Multicentre
- hsTnT measured during the first 3 postoperative days in all patients
Main finding
30-day all-cause mortality
Adjusted odds ratio
4.7
95% CI 3.0–7.4
By group
MINS vs No MINS
aOR 4.7 (95% CI 3.0–7.4)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | MINS, no ischemic features | MINS, ≥1 clinical ischemic feature |
|---|---|---|
| 30-day mortality by ischemic features (subgroup) | 5.4% (95% CI 3.7%–7.7%) | 10.6% (95% CI 6.7%–15.8%) |
Incidence of MINS
- Incidence of MINS
- 16.3% (95% CI, 15.3-17.4%)
MINS without ischemic symptoms
- Proportion of MINS without ischemic symptoms
- 89.9% (95% CI, 87.5-92.0)
Original publication
Myocardial Injury After Noncardiac Surgery in Major General Surgical Patients a Prospective Observational Cohort Study. Ann Surg. Published 17 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →