Cardiac arrest & resuscitation
Myoclonus in comatose patients with electrographic status epilepticus after cardiac arrest: Corresponding EEG patterns, effects of treatment and outcomes
Authors' conclusion
Myoclonus in comatose patients after cardiac arrest with RPPs is associated with poor outcome and discontinuous or suppressed EEG. However, presence of myoclonus does not interact with the effects of anti-seizure medication and cannot predict a poor outcome without false positives.
Study context
- Population
- Adult comatose post-cardiac arrest patients with rhythmic and periodic EEG patterns (RPPs) on continuous EEG, 11 ICUs in the Netherlands and Belgium
- Participants
- 157 patients
- Comparison
- Myoclonus vs no myoclonus
- Myoclonusn = 98
Methodological detailspost hoc analysis, multicentre
- Post hoc analysis
- Multicentre
Primary result
As reported in the abstract
Associations of myoclonus with EEG pattern and outcome
Myoclonus
- Continuous EEG background
- 48%
- RPP onset within 24 h after cardiac arrest
- 24%
- Poor neurological outcome at 3 months
- 96%
No myoclonus
- Continuous EEG background
- 75%
- RPP onset within 24 h after cardiac arrest
- 9%
- Poor neurological outcome at 3 months
- 82%
Continuous EEG background
Myoclonus48%
No myoclonus75%
RPP onset within 24 h after cardiac arrest
Myoclonus24%
No myoclonus9%
Poor neurological outcome at 3 months
Myoclonus96%
No myoclonus82%
Myoclonus vs No myoclonusOdds ratio (95% CI)
Continuous EEG background
0.31(0.16–0.64)
RPP onset within 24 h
3.86(1.64–9.11)
Further findings
| Outcome | Anti-seizure medication | Control | OR (95% CI) | |
|---|---|---|---|---|
| Good outcome with anti-seizure medication, regardless of myoclonus | 6% | 2% | 0.33 (0.03–3.32) | |
| 0.050.21520Odds ratio (log scale) |
Good outcome with anti-seizure medication, regardless of myoclonus
- Anti-seizure medication did not improve outcome, regardless of myoclonus presence
Original publication
Myoclonus in comatose patients with electrographic status epilepticus after cardiac arrest: Corresponding EEG patterns, effects of treatment and outcomes. Resuscitation. Published 22 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →