Cardiac arrest & resuscitation
Naloxone and Clinical Outcomes in Suspected Opioid-Associated Out-of-Hospital Cardiac Arrests
Main findingResult — go to the resultARD 2.75 pp 95% CI 1.25–4.26Authors' conclusion
In this cohort study, among patients with suspected OA-OHCA, EMS-administered naloxone was associated with improved survival and neurologic status and sustained ROSC.
Study context
- Population
- Adults with emergency medical services (EMS)-treated suspected opioid-associated OHCA (Naloxone Cardiac Arrest Decision Instrument (NACARDI): age <50 years, unwitnessed arrest), California Resuscitation Outcomes Consortium, 2021–2022meeting NACARDI criteria
- Participants
- 3,811 adults
- Exposure
- EMS-administered naloxone vs no naloxone
- Naloxonen = 1,251
- No naloxonen = 2,560reference
- Outcome
- Survival to hospital discharge
Methodological detailsinverse probability weighted
- Inverse probability weighted
Main finding
As reported in the abstract
ARD
2.75 pp
95% CI 1.25–4.26
Events by group
Naloxone vs No naloxone
ARD 2.75 pp (95% CI 1.25–4.26)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Naloxone | No naloxone | Estimate | |
|---|---|---|---|---|
| Favorable neurologic outcomeAdjusted | 7.4% | 3.3% | ARD 3.18 pp (95% CI 1.79–4.57) | |
| Sustained ROSCAdjusted | 14.1% | 9.6% | ARD 3.27 pp (95% CI 1.11–5.43) | |
| Survival to hospital discharge, patients who received epinephrine (sensitivity analysis) | adjusted ARD 0.31 pp (95% CI −0.09 to 1.58) | |||
| −50510Difference, pp (linear scale) |
Survival to hospital discharge, patients who received epinephrine (sensitivity analysis)
- Naloxone not associated with improved survival or the other clinical outcomes in patients who received epinephrine
Original publication
Naloxone and Clinical Outcomes in Suspected Opioid-Associated Out-of-Hospital Cardiac Arrests. JAMA Netw Open. Published 1 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →