Pediatric anesthesia & critical care
Needleless inhaled anesthesia with sevoflurane: Advantages of a simplified approach for children with spinal muscular atrophy undergoing intrathecal administration of nusinersen
Authors' conclusion
In this single-center experience, needleless general anesthesia with inhaled sevoflurane without imaging guidance has been shown to be feasible for children with spinal muscular atrophy undergoing lumbar puncture for nusinersen administration.
Study context
- Population
- Children with spinal muscular atrophy undergoing intrathecal nusinersen administration (lumbar puncture), 24-month period250 lumbar punctures
- Participants
- 116 children
- Outcome
- Number of predefined sentinel adverse events related to anaesthesia
Methodological detailssingle-centre, no imaging guidance
- Single-centre
- No imaging guidance
Main finding
As reported in the abstract
Cases of prolonged desaturation (sentinel adverse events) during anesthesia, of 250 lumbar punctures
2
Proportion of sentinel adverse events
0.8%
Observational data: associations, not effects.
Secondary outcomes
Number of lumbar puncture attempts
- Mean number of puncture attempts (SD 1.3)
- 1.6
Duration of the procedure
- Mean duration of the procedure, minutes (SD 8.3)
- 14.1
Failures in drug administration
- Failures in drug administration
- 0
Safety
Orotracheal intubation, unplanned PICU admission, unplanned or prolonged hospitalisation
- No patient intubated or with unplanned PICU admission
- No patient with unplanned or prolonged hospitalisation after the procedure
Original publication
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