Pediatric anesthesia & critical care
The Influence of Electroencephalographic Density Spectral Array Guidance of Sevoflurane Administration on Recovery From General Anesthesia in Children. A Randomized Controlled Trial
Authors' conclusion
This randomized controlled trial provides initial evidence of an added value of density spectral array monitoring in terms of the speed of recovery and allows sevoflurane to be dosed 22% lower during maintenance than with a more traditional approach using a minimal alveolar concentration of 0.9.
Study context
- Population
- Children aged 6 months-12 years having elective surgery under GA supplemented with caudal analgesia96 analysed
- Comparison
- Density spectral array vs Standard care
- Primary endpoint
- Time from sevoflurane discontinuation to meeting operating room discharge criteria (Steward score of 3 or more)
Primary result
As reported in the abstract
Time until discharge readiness from the operating room
Difference between medians
6 min
95% CI −7 to 0
P = 0.041
By group
Further findings
Mean
| Outcome | Density spectral array | Standard care | Estimate | P value |
|---|---|---|---|---|
| Mean end-tidal sevoflurane concentration during surgery | 1.8% | 2.3% | (95% CI 0.4–0.7) | P < 0.001 |
- Mean end-tidal sevoflurane concentration during surgery: values printed as 1.8% (0.34) versus 2.3% (0.1)
Original publication
The Influence of Electroencephalographic Density Spectral Array Guidance of Sevoflurane Administration on Recovery From General Anesthesia in Children. A Randomized Controlled Trial. Paediatr Anaesth. Published 13 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →