Pediatric anesthesia & critical care
Electroencephalographic density spectral array monitoring during propofol/sevoflurane coadministration in children, an exploratory observational study
Authors' conclusion
DSA-guided augmentation of propofol anesthesia with sevoflurane provides sufficient depth of anesthesia at doses usually considered sub-anesthetic in children, leading to less anesthetic drug exposure for the individual child.
Study context
- Population
- Children from birth to 11 years under propofol/sevoflurane anaesthesia with fixed sevoflurane and variable propofol dosagessuitable for analysis
- Participants
- 78 children
- Outcome
- Correlation between variable propofol dosages and expression of the four EEG frequency bands β, α, θ, δ
Main finding
As reported in the abstract
Correlation of propofol dosage with relative percentage of EEG bands (patients >1 year)
Dose-dependent correlation with relative percentage of β, p < 0.001
−12.2%
Dose-dependent correlation with relative percentage of δ, p < 0.001
5.1%
Observational data: associations, not effects.
Secondary outcomes
Intra-operative total EEG power
- Age-dependent trend toward increasing mean EEG power, most significant increase in the first year of life
Burst suppression (at least one episode)
- Prevalence of at least one episode of burst suppression
- 14.1%
Original publication
Electroencephalographic density spectral array monitoring during propofol/sevoflurane coadministration in children, an exploratory observational study. Anaesth Crit Care Pain Med. Published 22 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →