Pediatric anesthesia & critical care
Electroencephalographic delta and alpha oscillations reveal phase-amplitude coupling in paediatric patients undergoing sevoflurane-based general anaesthesia
Main finding · Strength of delta-alpha phase-amplitude coupling (mean amplitude vector)Result — go to the resultWilcoxon paired signed-rank test Z=3.107Authors' conclusion
Sevoflurane-based anaesthesia is associated with delta-alpha phase-amplitude coupling in paediatric patients.
Study context
- Population
- Paediatric patients aged 10 months to 3 yr undergoing elective surgery with sevoflurane-based anaesthesiaretrospective EEG data
- Participants
- 31 patients
- Exposure
- Maintenance of sevoflurane-based GA vs emergence
- Outcome
- Delta-alpha phase-amplitude coupling (EEG)
Methodological detailspaired comparison (anaesthesia vs emergence)
- Paired comparison (anaesthesia vs emergence)
Main finding
As reported in the abstract
Strength of delta-alpha phase-amplitude coupling (mean amplitude vector)
Wilcoxon paired signed-rank test
Z=3.107
P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | General anaesthesia | Emergence |
|---|---|---|
| Distribution of frontal alpha amplitude across delta phases (omnibus circular uniformity) | mean phase 114º (99% CI 90º-139º) | mean phase 181º (99% CI 110º-253º) |
| Omnibus P | P<0.001 | P=0.35 |
Distribution of frontal alpha amplitude across delta phases (omnibus circular uniformity)
- During GA, alpha power restricted to the positive phase of the delta wave
Original publication
Electroencephalographic delta and alpha oscillations reveal phase-amplitude coupling in paediatric patients undergoing sevoflurane-based general anaesthesia. Br J Anaesth. Published 13 March 2023. doi:10.
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