Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study
Authors' conclusion
ECM turnover is induced in a model of systemic inflammation in healthy volunteers and was observed in patients with septic shock.
Study context
- Population
- Healthy male volunteers challenged with lipopolysaccharide (LPS) and patients with septic shock
- Participants
- 10 vs 43
- Exposure
- Extracellular matrix (ECM) turnover neo-epitopes after LPS challenge vs baseline; septic shock patients vs healthy controls
- LPS challengen = 10
- Septic shockn = 43
- Outcome
- Circulating ECM turnover neo-epitopes (degradation: C1M, C3M, C4Ma3, C6M, ELP-3, X-FIB; synthesis: PRO-C3, PRO-C4, PRO-C6) by ELISA
Methodological detailshuman endotoxaemia model, observational septic shock cohort
- Human endotoxaemia model
- Observational septic shock cohort
Main finding
As reported in the abstract
- 24 h after LPS, all ECM turnover neo-epitopes except ELP-3 increased vs baseline
- In septic shock, all ECM neo-epitopes higher vs healthy controls
Observational data: associations, not effects.
Further findings
C6M, ELP-3 and X-FIB in septic shock non-survivors vs survivors · day 1 of ICU admission
- Concentrations of C6M, ELP-3 and X-FIB higher in patients with septic shock who did not survive (N = 7) vs those who recovered (N = 36)
Original publication
Neo-epitope detection identifies extracellular matrix turnover in systemic inflammation and sepsis: an exploratory study. Crit Care. Published 12 April 2024. doi:10.
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