Pediatric anesthesia & critical care
Neurodevelopmental and behavioural disorders after perioperative invasive mechanical ventilation in paediatric surgical admissions
Authors' conclusion
Children receiving invasive mechanical ventilation during a surgical admission are at increased risk of neurodevelopmental and behavioural disorders after hospital discharge.
Study context
- Population
- Children enrolled in Texas Medicaid 1999–2012 with a surgical admissionsurgical admissions meeting eligibility
- Participants
- 35,161 children
- Exposure
- Paediatric intensive care unit (PICU) with invasive mechanical ventilation (IMV), PICU without IMV, or intermediate medical care unit (IMCU) vs general ward
- PICU with IMVn = 993
- PICU without IMVn = 7,670
- IMCUn = 1,027
- Outcome
- Post-discharge neurodevelopmental and behavioural disorders (NDBD)
Methodological detailsTexas Medicaid claims
- Texas Medicaid claims
Main finding
As reported in the abstract
Each group vs general wardHazard ratio (95% CI)P value
PICU with IMV
1.91(1.27–2.89)
P = 0.002PICU without IMV
1.12(0.98–1.29)
P = 0.10IMCU
0.88(0.61–1.26)
P = 0.48Observational data: associations, not effects.
Further findings
Neurodevelopmental and behavioural disorders (NDBD) by IMV duration
- Elevated NDBD rates primarily with IMV for 96 h or more
Post-discharge psychotropic medication use
- Increased only in the IMV group
Original publication
Neurodevelopmental and behavioural disorders after perioperative invasive mechanical ventilation in paediatric surgical admissions. Br J Anaesth. Published 13 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →