Behavioural disorders after prenatal exposure to anaesthesia for maternal surgery
Main finding · Disruptive or internalising behavioural disorder diagnosisResult — go to the resultHazard ratio 1.31 95% CI 1.23–1.40Authors' conclusion
Prenatal exposure to general anaesthesia is associated with a 31% increased risk for a subsequent diagnosis of a disruptive or internalising behavioural disorder in children.
Study context
- Population
- Liveborn children of pregnant women in the US Medicaid Analytic eXtract (MAX, 1999–2013)matched cohort
- Participants
- 34,271 vs 171,355
- Exposure
- Exposed vs Unexposed
- Exposedn = 34,271
- Unexposedn = 171,355reference
- Outcome
- Diagnosis of a disruptive or internalising behavioural disorder in children
Methodological detailsmultivariate matching, nationwide Medicaid database (MAX)
- Multivariate matching
- Nationwide Medicaid database (MAX)
Main finding
As reported in the abstract
Disruptive or internalising behavioural disorder diagnosis
Hazard ratio
1.31
95% CI 1.23–1.40
Exposed vs Unexposed
HR 1.31 (95% CI 1.23–1.40)
Observational data: associations, not effects.
Secondary outcomes
Disruptive behavioural disorder
- HR, exposed vs unexposed
- 1.32 (95% CI 1.24-1.41)
Internalising behavioural disorder
- HR, exposed vs unexposed
- 1.36 (95% CI 1.20-1.53)
Attention-deficit/hyperactivity disorder
- HR, exposed vs unexposed
- 1.32 (95% CI 1.22-1.43)
Behavioural disorders
- HR, exposed vs unexposed
- 1.28 (95% CI 1.14-1.42)
Developmental speech or language disorders
- HR, exposed vs unexposed
- 1.16 (95% CI 1.05-1.28)
Autism
- HR, exposed vs unexposed
- 1.31 (95% CI 1.05-1.64)
Original publication
Behavioural disorders after prenatal exposure to anaesthesia for maternal surgery. Br J Anaesth. Published 29 February 2024. doi:10.
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