The Association of Pregnancy With Outcomes Among Critically Ill Reproductive-Aged Women: A Propensity Score-Matched Retrospective Cohort Analysis
Authors' conclusion
In this large US cohort, critically ill pregnant women receiving MV or with sepsis showed better survival than propensity score-matched nonpregnant women.
Study context
- Population
- Women 18 to 55 years receiving invasive mechanical ventilation (MV) on hospital day 0 or 1 or with sepsis on admission, Premier Healthcare Database hospitals, 2008–20213,093 MV pairs
- Exposure
- Pregnant vs nonpregnant critically ill women
- Outcome
- In-hospital mortality
Methodological details1:1 propensity score matched within age strata, multilevel multivariable mixed-effects logistic regression
- 1:1 propensity score matched within age strata
- Multilevel multivariable mixed-effects logistic regression
Main finding
As reported in the abstract
Pregnant vs NonpregnantOdds ratio (95% CI)P value
MV cohort, adjusted
0.50(0.41–0.60)
P < 0.001Sepsis cohort, adjusted
0.52(0.40–0.67)
P < 0.001Observational data: associations, not effects.
Original publication
The Association of Pregnancy With Outcomes Among Critically Ill Reproductive-Aged Women: A Propensity Score-Matched Retrospective Cohort Analysis. Chest. Published 20 March 2024. doi:10.
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