Opioid analgesic exposure during the first trimester of pregnancy and the risk of major congenital malformations in infants: a systematic review and meta‐analysis †
Pooled result · Major congenital malformations overallResult — go to the resultRelative risk 1.04 95% CI 0.98–1.11Authors' conclusion
Although the meta-analysis did not indicate substantial increased risk for most malformations examined, this risk remains uncertain due to the methodological limitations of the included studies.
Study context
- Population
- Infants exposed to opioid analgesics in the first trimester (excluding opioid agonist therapy or illicit opioid use)12 studies
- Comparison
- First-trimester opioid analgesic exposure vs unexposed
- Outcome
- Major congenital malformations
Methodological detailsrandom-effects meta-analysis, ROBINS-I risk of bias assessment
- Random-effects meta-analysis
- ROBINS-I risk of bias assessment
Pooled result
Major congenital malformations overall
Relative risk
1.04
95% CI 0.98–1.11
Any opioid vs Unexposed
RR 1.04 (95% CI 0.98–1.11)
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Cardiovascular malformations | 1.07 (0.96–1.20) | |
| Central nervous system malformations | 1.06 (0.92–1.21) | |
| Gastrointestinal malformations | 1.40 (0.38–5.16) | |
| Cleft palate | 1.57 (0.48–5.13) | |
| Atrial septal defects (codeine exposure)Codeine vs Unexposed | 1.20 (1.05–1.36) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Opioid analgesic exposure during the first trimester of pregnancy and the risk of major congenital malformations in infants: a systematic review and meta‐analysis †. Anaesthesia. Published 7 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →