Pediatric anesthesia & critical care
Neurodevelopmental Outcomes after Multiple General Anesthetic Exposures before 5 Years of Age: A Cohort Study
Main findingResult — go to the resultmean −5.8 points 95% CI −10.2 to −1.4Authors' conclusion
Multiple general anesthetic exposures before 5 yr of age were associated with reduced performance in general intelligence score and some domains of neurodevelopmental assessments.
Study context
- Population
- Children from the GAS trial database (infants who had elective inguinal herniorrhaphy)complete assessment available
- Participants
- 90 vs 141
- Exposure
- Multiple GA exposures vs one or no GA exposure before 5 yr of age
- Multiple GAn = 90
- No or one GAn = 141reference
- Outcome
- Full-scale IQ on the Wechsler Preschool and Primary Scale of Intelligence (third edition)
- Follow-up
- 5 yr of age
Methodological detailssecondary analysis of the GAS trial database, observational, Significant residual confounding cannot be excluded due to observational nature
- Secondary analysis of the GAS trial database
- Observational
- Significant residual confounding cannot be excluded due to observational nature
Main finding
As reported in the abstract
mean
−5.8 points
95% CI −10.2 to −1.4
P = 0.011
Observational data: associations, not effects.
Secondary outcomes
- Lower verbal and performance IQ scores and more emotional, behavioral and executive function difficulties in multiply exposed children
Original publication
Neurodevelopmental Outcomes after Multiple General Anesthetic Exposures before 5 Years of Age: A Cohort Study. Anesthesiology. Published 11 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →