Cardiothoracic & vascular anesthesia
Anesthesia and Sedation Exposure and Neurodevelopmental Outcomes in Infants Undergoing Congenital Cardiac Surgery: A Retrospective Cohort Study
Primary result · Bayley III scores by cumulative exposureResult — go to the resultPoint decrease in Bayley III motor score 0.34 points 95% CI −0.64 to −0.05Authors' conclusion
Total cumulative exposures to volatile anesthetic agents were not associated with neurodevelopmental impairment in infants with congenital heart disease undergoing various imaging studies and procedures, whereas higher ketamine doses were associated with poorer motor performance.
Study context
- Population
- Infants with congenital heart disease undergoing cardiac surgery, imaging studies and procedures
- Participants
- 41 vs 69
- Comparison
- Cumulative exposure to volatile anaesthetics and sedative/anaesthesia medications (dose–response)
- Single-ventriclen = 41
- Two-ventriclen = 69
- Primary endpoint
- Bayley III neurodevelopmental scores
- Follow-up
- 18 months of age
Methodological detailsretrospective
- Retrospective
Primary result
Bayley III scores by cumulative exposure · 18 months
Point decrease in Bayley III motor score
0.34 points
95% CI −0.64 to −0.05
P = 0.024
As reported in the abstract
Original publication
Anesthesia and Sedation Exposure and Neurodevelopmental Outcomes in Infants Undergoing Congenital Cardiac Surgery: A Retrospective Cohort Study. Anesthesiology. Published 13 July 2023. doi:10.
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