Cardiac arrest & resuscitation

Neuroprognostication in Extracorporeal Membrane Oxygenation Patients After Cardiac Arrest: A Narrative Review

J Cardiothorac Vasc AnesthPublished Narrative review

Authors' conclusion

Although neuroprognostication in ECMO patients is uncertain and difficult, available instruments may provide key prognostic information when used with appropriate caution and by expert interpreters.

Study context

Population
Extracorporeal membrane oxygenation (ECMO)-supported patients following cardiac arrest
Outcome
Accuracy of neuroprognostic tools in ECMO patients after cardiac arrest
Methodological detailsnarrative systematic review, literature 2014–2024
  • Narrative systematic review
  • Literature 2014–2024

Pooled result

As reported in the abstract

  • Traditional neuroprognostic tools perform reasonably well in ECMO patients, with caveats
  • Neuron-specific enolase increased by hemolysis
  • EEG and evoked potentials unreliable
  • MRI contraindicated
  • Multimodal approach with at least two criteria for poor outcome seems justified in ECMO and non-ECMO populations

Original publication

Neuroprognostication in Extracorporeal Membrane Oxygenation Patients After Cardiac Arrest: A Narrative Review. J Cardiothorac Vasc Anesth. Published 27 October 2025. doi:10.1053/j.jvca.2025.10.011

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