Respiratory failure & ventilation
Neutrophil-to-Lymphocyte Ratio: A Promising Predictor of Mortality in Patients With Acute Respiratory Distress Syndrome. A Retrospective Analysis of a Single Hospital Center
Authors' conclusion
In this retrospective single-center study, the NLR was a potential predictor of both short- and long-term mortality in patients with ARDS and may aid risk stratification.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS) in a critical care unit
- Participants
- 785 patients
- Exposure
- Neutrophil-to-lymphocyte ratio (NLR) groups: NLR 6.0-11.3 and NLR >11.3 vs NLR <6.0
- Outcome
- 30-day all-cause mortality
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Each group vs group 1Hazard ratio (95% CI)P value
Group 2unadjusted
1.12(0.83–1.52)
Group 3unadjusted
2.39(1.87–3.04)
Group 3adjusted for potential confounders
1.54(1.18–2.02)
P = 0.0004for trendObservational data: associations, not effects.
Further findings
90-day and 1-year all-cause mortality
- A similar effect was seen on both 90-day and 1-year all-cause mortality
2-piecewise linear regression, left of inflection point (NLR 17.1)
- R2 value
- 1.25 (95% CI, 1.06-1.48; p < 0.0001)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Neutrophil-to-Lymphocyte Ratio: A Promising Predictor of Mortality in Patients With Acute Respiratory Distress Syndrome. A Retrospective Analysis of a Single Hospital Center. J Cardiothorac Vasc Anesth. Published 27 March 2024. doi:10.
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