Hemodynamics, fluids & transfusion
Nitric oxide biomarkers and circulatory failure in critical illness: A cohort study
Authors' conclusion
Increased ADMA and arginine at admission are associated with decreased norepinephrine treatment on the first three days of ICU admission. Increased homoarginine concentrations are associated with increasing plasma lactate.
Study context
- Population
- Adult ICU patients with nitric oxide (NO)-biomarkers at admission
- Participants
- 527 patients
- Exposure
- NO-biomarkers (asymmetrical dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, homoarginine) at admission vs norepinephrine treatment and plasma lactate
- Outcome
- Norepinephrine treatment and highest daily plasma lactate
- Follow-up
- ICU days 1-3
Main finding
As reported in the abstract
Norepinephrine treatment · ICU day 1
Odds ratio (95 % CI)P value
ADMA (pr 1 μmol/L)
0.36(0.17–0.78)
P = 0.009Arginine (pr 10 μmol/L)
0.85(0.79–0.92)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Increase in plasma lactate (%) (95 % CI) | |
|---|---|---|
| Plasma lactate per 1 μmol/L increase in homoarginineHomoarginine (per 1 μmol/L) · ICU days 1-2 | 6 (−2 % to 15 %) | |
| Plasma lactate per 1 μmol/L increase in homoarginineHomoarginine (per 1 μmol/L) · ICU days 2-3 | 4 (−4 % to 13 %) | |
| −1001020Difference, % (linear scale) |
Plasma lactate per 1 μmol/L increase in homoarginine
- SDMA not associated with plasma lactate
Original publication
Nitric oxide biomarkers and circulatory failure in critical illness: A cohort study. J Crit Care. Published 16 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →