Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial
Primary resultResult — go to the resultDifference in means −0.57 points 95% CI −1.42 to 0.28Authors' conclusion
Compared with air/oxygen, 2 hours of nitrous oxide/oxygen exposure for three sessions did not provide meaningful therapeutic potential for patients with chronic CRPS.
Study context
- Population
- Patients with a diagnosis of Complex Regional Pain Syndrome (CRPS)
- Participants
- 44 patients
- Comparison
- Nitrous oxide exposure vs placebo air/oxygen mixture
- Nitrous Oxiden = 20
- Air-Oxygenn = 24reference
- Primary endpoint
- Patient-reported pain scores
- Follow-up
- 1 week and 1 month
Methodological detailsblinded, placebo-controlled
- Blinded
- Placebo-controlled
Primary result
As reported in the abstract
Difference in means
−0.57 points
95% CI −1.42 to 0.28
P = 0.19
Nitrous Oxide vs Air-Oxygen
difference in means −0.57 points (95% CI −1.42 to 0.28); P = 0.19
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| Physical health (PROMIS-29 v2, mean Z-score) | difference in mean Z-scores 0.13 (95% CI −0.16 to 0.43) | |
| Mental health (mean Z-score) | difference in mean Z-scores 0.087 (95% CI −0.31 to 0.48) | |
| Patient Global Impression of Change score | difference −0.7 (95% CI −1.85 to 0.46) | |
| −2−101Difference (linear scale) |
Original publication
Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial. Reg Anesth Pain Med. Published 28 October 2023. doi:10.
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