Virtual reality compared to nitrous oxide for labor analgesia: a feasibility pilot, prospective, randomized, cross-over, non-inferiority study
Primary result · Satisfaction with pain reliefResult — go to the resultDifference 0.65 90 % CI −0.66 to 1.95Authors' conclusion
Data from this pilot study suggest that VR is a promising non-pharmacological analgesic option that is non-inferior to N2O for labor pain management.
Study context
- Population
- Parturients in labor18 completed
- Participants
- 20 participants
- Comparison
- Virtual reality (VR) vs nitrous oxide for labor analgesia
- Primary endpoint
- Satisfaction with pain relief (verbal NRS 0–10) post-intervention
- Follow-up
- 30 minutes
Methodological detailsprospective, crossover, non-inferiority, feasibility pilot
- Prospective
- Crossover
- Non-inferiority
- Feasibility pilot
Primary result
Satisfaction with pain relief · 30 min
Difference
0.65
90 % CI −0.66 to 1.95
VR vs N2O
difference 0.65 (90 % CI −0.66 to 1.95)
As reported in the abstract
Secondary outcomes
| Outcome | Difference (90 % CI) | |
|---|---|---|
| Satisfaction with pain relief · 15 minNon-inferior | −0.24 (−1.53 to 1.06) | |
| −2−1012Difference (linear scale) |
Change in pain, anxiety, coping
- VR non-inferior to nitrous oxide (N2O) for change in pain, anxiety, and coping
Original publication
Virtual reality compared to nitrous oxide for labor analgesia: a feasibility pilot, prospective, randomized, cross-over, non-inferiority study. Int J Obstet Anesth. Published 25 August 2025. doi:10.
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