Perioperative medicine & outcomes
Novel biological risk factors for 7‐day postoperative kidney injury in elective major non‐cardiac surgery: a retrospective observational study
Authors' conclusion
Postoperative acute kidney injury is common and is associated with adverse outcomes.
Study context
- Population
- Elective major non-cardiac surgical episodes, 2015–2020, with measured peri-operative renal parameters
- Participants
- 13,790 surgical episodes
- Outcome
- Postoperative AKI rate (Kidney Disease Improving Global Outcomes criteria)
- Follow-up
- 7 days
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
As reported in the abstract
7-day postoperative AKI (KDIGO criteria)
Postoperative AKI, episodes
1334 of 13,790
9.7%
Postoperative AKI occurring on day 1
663
49.7%
Observational data: associations, not effects.
Further findings
Outcomes associated with postoperative AKI
| OR (95% CI) | P value | ||
|---|---|---|---|
| Peri-operative complications | 1.8 (1.6–2.1) | P < 0.001 | |
| Unanticipated critical care admissions | 2.4 (1.6–3.5) | P < 0.001 | |
| In-hospital mortality | 8.0 (5.1–12.5) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Independent risk factors for postoperative AKI
- Raised creatinine; hypertension; anaemia; platelet: lymphocyte ratio; heart rate; male sex; renin-angiotensin-aldosterone system blockade; intra-abdominal surgery
Original publication
Novel biological risk factors for 7‐day postoperative kidney injury in elective major non‐cardiac surgery: a retrospective observational study. Anaesthesia. Published 13 March 2025. doi:10.
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