Nucleated red blood cells as a prognostic marker for mortality in septic critically ill patients: An observational study
Authors' conclusion
Measuring NRBCs can help predict mortality in septic critically ill patients with high prognostic accuracy. A cut-off of ≥100/µL for NRBCs appears to effectively stratify the study population regarding mortality.
Study context
- Population
- Septic critically ill patients in the intensive care unit (ICU), 2020–2023analysed
- Participants
- 465 patients
- Exposure
- Maximum NRBC ≥100/µL vs <100/µL during ICU stay
- Outcome
- Predictive validity of nucleated red blood cells (NRBCs) for mortality
Main finding
As reported in the abstract
Maximum NRBC value during ICU stay
P < 0.001
- ICU mortality discrimination, max NRBC cut-off ≥100/µL (AUC)
- 0.745; 95% CI 0.693-0.797; p < 0.001
- Max NRBC ≥100/µL, odds of death (OR)
- 5.03; 95% CI 3.19-7.90; p < 0.001
- Max NRBC ≥100/µL, mortality (Cox HR)
- 1.84; 95% CI 1.16-2.98; p = 0.012
Observational data: associations, not effects.
Original publication
Nucleated red blood cells as a prognostic marker for mortality in septic critically ill patients: An observational study. Anaesth Crit Care Pain Med. Published 29 September 2025. doi:10.
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